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Safety and Tolerability of the Oral Xa Inhibitor Darexaban for Secondary Prevention After Acute Coronary Syndromes: the RUBY-1 Trial

Hot Line III - Acute Coronary Syndromes

Topics: Acute Coronary Syndromes (ACS)

Paris, France, 30 August: A phase II dose-finding study has found that the new oral Factor Xa inhibitor darexaban was associated with a two to four-fold increase in bleeding when added to dual antiplatelet therapy in patients following an acute coronary syndrome.

Professor Gabriel Steg from the Hôpital Bichat in Paris, presenting results from the RUBY-1 trial in a Hot Line session of the ESC Congress today, said the study produced no other safety concerns and that "establishing the role of low-dose darexaban in preventing major cardiac events after ACS now requires a large phase III trial".

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